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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Neuropathol Appl Neurobiol. 2010 Oct;36(6):462–477. doi: 10.1111/j.1365-2990.2010.01103.x

Fig. 4.

Fig. 4

Representative photomicrographs from the brain stem of 8-month-old JNPL3 mouse showing cells immunoreactive for only activated SFK (a-c) or phospho-Tyr18 tau (d-f). When activated SFK and phospho-Tyr18 appeared in the same cell in the entorhinal cortex, the subcellular distribution was either different (g-i) or overlapping (jl). Scale bar: 20μm. (m) Percentage of positive cells immunoreactive for phospho-Tyr18 tau (9G3) alone (dark blue triangles), active-Src (pY416) alone (light blue squares) or for both (red circles) with increasing age in different brain regions of JNPL3 mice. The total number of positive cells per age group in respective brain regions was counted following double labeling with 9G3 and pY416 antibodies and assigned 100%. Hippocampus had no labeled cells at 4 and 6 months, then showed only double-labeled cells (both 9G3 and pY416 positive) at 8 months.