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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Cytokine Growth Factor Rev. 2010 Aug 4;21(4):299–313. doi: 10.1016/j.cytogfr.2010.06.003

Figure 1.

Figure 1

Figure showing the involvement of various BMP molecules and their receptors in complex and multi-step molecular process of human cancer. The four outer circles are representing the events reported to be associated with progression of cancer. Outermost text boxes are showing a snapshot about the particular BMPs, BMPR, and the way these are involved in various cancerous processes either protectively or anti-protectively. These cancerous processes decides the fate of a living cell in its micro environment. Text box A, showing role of BMPs in EMT and MET; text box B, showing expression, over expression and copy number alteration in BMPs and BMPRs during cancer; text box C, showing BMPs during growth, proliferation, metastasis and angiogenesis; and text box D, showing the association of mutations, SNPs, microRNA with BMPs and their receptors and relation with epigenetic regulation during various human cancer. In the center of the figure the text CANCER and two symbol upward ( ) and downward triangle ( ), means these different BMPs may increase and decrease the incidence of human cancer in various cell, tissue and cancer type.