. Author manuscript; available in PMC: 2011 Aug 1.

Published in final edited form as: Cytokine Growth Factor Rev. 2010 Aug 4;21(4):299–313. doi: 10.1016/j.cytogfr.2010.06.003

Table 2.

BMPs and their involvement during the process of metastasis, cell migration, invasion and angiogenesis

Serial No.	Cancer type	BMPs involved	Cancer processes metastasis, angiogenesis, motility, invasiveness, adhesion	References
1.	Prostate cancer	BMP4	Increases adhesion of PC-3 cells to the endothelium of bone marrow	[89, 91]
	Prostate cancer	BMP7	An inducer for EMT with changes in the morphology, motility, invasiveness, and molecular markers	[19]
	Prostate cancer	BMP2	Enhances the invasivess of C4-2B cells	[92]
	Metastatic bone lesions of prostate cancer	BMP7	Metastasis	[118]
	Prostatic adenocarcinomas both in primary tumor and in skeletal metastases	BMP6	Metastasis	[83]
2.	Breast cancer cells	BMP2 and BMP3	Metastasis	[48]
	Breast cancer	BMP7	Metastasis to bone	[95]
	Breast cancer	BMP7	Cell migration and invasion	[53]
	Breast cancer cells	BMP6	Inhibits metastasis and EMT	[102]
	Breast cancer	BMP4	Cell migration and invasion	[79]
3.	Malignant melanoma cells	BMP2	Metastasis	[23]
	Melanoma	BMP4 and BMP7	Promotion of melanoma cell invasion, migration, and progression	[23]
		BMP2 and BMP4	Tube formation as well as migration in the micro-vascular network of melanoma	[124]
		BMP7	Potential metastasis inhibitor	[117]
4.	Oral carcinoma	BMP2, -4, and -5	Metastasis	[41]
5.	Gastric cancer	BMP2	Motility and invasiveness	[84]
5.	Gastric cancer	BMP2	Metastasis	[97]
6.	Giant cell tumor	BMP2–6	Metastasis	[40]
7.	Osteogenic sarcoma-derived Saos-2 and HOS cell lines	BMP2	Regulator of cell adhesion	[109]
8.	Primary human epithelial ovarian cancerous cells	BMP4 signaling	Changes in cellular morphology adhesion, motility, invasion, and alteration of EMT markers Snail and Slug	[125]
9.	Malignant epithelial cells	BMP6	Metastasis	[100]
10.	Human colorectal cells	BMP4	Changes in cellular morphology, expression of vimentin a EMT marker, migration and invasion	[115, 116]
11.	NSCLC	BMP2	Enhances migration and invasion in vivo	[32]
12.	Bladder carcinoma	BMP2	Heterotopic ossification in metastatic lesions from urothelial bladder carcinoma	[96]
13.	Colon and kidney cancer cells	BMP7	Role in proinvasive activities like scattering	[107]