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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Mol Cancer Ther. 2009 May 12;8(5):1207–1217. doi: 10.1158/1535-7163.MCT-08-1097

Figure 6.

Figure 6

TA inhibits tumor (BT474 xenografts) growth. Inhibition of tumor volume (A) and weight (B). Athymic nude mice bearing BT474 cells as xenografts were treated with TA (25 mg/kg/d) and tumor volumes and weights were determined as described in the Materials and Methods. Significantly (p < 0.05) decreased tumor weights are indicated (*). (C) H&E staining and immunostaining. Tumors from vehicle control (corn oil)- and TA-treated mice were fixed and stained (H&E) and immunostaining for erbB2, phospho-MAPK, YY1 and AP-2 as described in the Materials and Methods. (D) A schematic model summarizing the effects of TA on erbB2 in BT474 and SKBR3 cells.