TABLE 3.

Magnitude of rightward shift for dose-effect curves of U50,488 and bremazocine in antinociception after nor-BNI pretreatment

	Dose Ratiosa
Days after nor-BNI	i.c. nor-BNI 0.32 mg		i.c. nor-BNI 0.032 mg		s.c. nor-BNI 0.32 mg
	versus U50,488	versus bremazocine	versus U50,488	versus bremazocine	versus U50,488	versus bremazocine
1	9.5*		3.0*		1.0
3		1.8		0.9		1.0
7	7.5*		2.5*		1.2
10		1.9		0.8		1.0
14	3.9*		1.0
21	7.9*		0.8
28		2.0		1.0
35	5.4*		0.7
42		0.7
49	1.5
56		1.0
63	1.0

^aDose ratios were mean of individual dose ratio values (n = 4).

^*Significant rightward shift of dose-effect curve *p < .05.