Skip to main content
. Author manuscript; available in PMC: 2010 Sep 15.
Published in final edited form as: Am J Psychiatry. 2010 Jun;167(6):630–639. doi: 10.1176/appi.ajp.2010.08101500

Table 1.

Topiramate Dose Escalation Schedule for Treatment of Alcohol Dependence

Week Morning Dose Afternoon Dose Total Daily Dose
1 0 mg 1×25-mg tablet 25 mg
2 0 mg 2×25-mg tablets 50 mg
3 1×25-mg tablet 2×25-mg tablets 75 mg
4 2×25-mg tablets 2×25-mg tablets 100 mg
5 2×25-mg tablets 1×100-mg tablet 150 mg
6 1×100-mg tablet 1×100-mg tablet 200 mg
7 1×100-mg tablet 1×100-mg and 2×25-mg tablets 250 mg
8 1×100-mg and 2×25-mg tablets 1×100-mg and 2×25-mg tablets 300 mg
9 1×100-mg and 2×25-mg tablets 1×100-mg and 2×25-mg tablets 300 mg
10 1×100-mg and 2×25-mg tablets 1×100-mg and 2×25-mg tablets 300 mg
11 1×100-mg and 2×25-mg tablets 1×100-mg and 2×25-mg tablets 300 mg
12 1×100-mg and 2×25-mg tablets 1×100-mg and 2×25-mg tablets 300 mg

Reprinted from Johnson et al. (53), with permission from Elsevier.