Table 3.
Top over-expressed Gene Ontology biological pathways associated mainly with up-regulated genes in RAC limbal epithelial progenitors
| GO ID | Gene Ontology (GO) Description | GO Type | Number of genes |
Z Score | |||||
|---|---|---|---|---|---|---|---|---|---|
| Up | Measured | in GO | % Up | %Present | |||||
| 1 | 19884 | antigen presentation\, exogenous antigen | P | 6 | 14 | 21 | 42.9 | 66.7 | 7.535 |
| 2 | 6817 | phosphate transport | P | 15 | 81 | 89 | 18.5 | 91.0 | 6.819 |
| 3 | 6029 | proteoglycan metabolism | P | 6 | 21 | 25 | 28.6 | 84.0 | 5.846 |
| 4 | 6024 | glycosaminoglycan biosynthesis | P | 5 | 16 | 18 | 31.2 | 88.9 | 5.656 |
| 5 | 16477 | cell migration | P | 12 | 76 | 80 | 15.8 | 95.0 | 5.371 |
| 6 | 15698 | inorganic anion transport | P | 17 | 134 | 146 | 12.7 | 91.8 | 5.283 |
| 7 | 30166 | proteoglycan biosynthesis | P | 4 | 13 | 16 | 30.8 | 81.2 | 5.008 |
| 8 | 9887 | organ morphogenesis | P | 18 | 167 | 179 | 10.8 | 93.3 | 4.623 |
| 9 | 30334 | regulation of cell migration | P | 4 | 16 | 17 | 25.0 | 94.1 | 4.364 |
| 10 | 44272 | sulfur compound biosynthesis | P | 5 | 24 | 29 | 20.8 | 82.8 | 4.29 |
| 11 | 8277 | G-protein coupled receptor protein signaling pathway | P | 5 | 25 | 26 | 20.0 | 96.2 | 4.163 |
| 12 | 30155 | regulation of cell adhesion | P | 5 | 31 | 31 | 16.1 | 100.0 | 3.522 |
| 13 | 6874 | calcium ion homeostasis | P | 8 | 65 | 67 | 12.3 | 97.0 | 3.511 |
| 14 | 6790 | sulfur metabolism | P | 7 | 53 | 59 | 13.2 | 89.8 | 3.509 |
| 15 | 42060 | wound healing | P | 9 | 80 | 87 | 11.2 | 92.0 | 3.408 |
| 16 | 1558 | regulation of cell growth | P | 10 | 103 | 108 | 9.7 | 95.4 | 3.059 |
| 17 | 5201 | extracellular matrix structural constituent | F | 21 | 79 | 85 | 26.6 | 92.9 | 10.448 |
| 18 | 45012 | MHC class II receptor activity | F | 6 | 14 | 21 | 42.9 | 66.7 | 7.535 |
| 19 | 5520 | insulin-like growth factor binding | F | 5 | 18 | 20 | 27.8 | 90.0 | 5.238 |
| 20 | 30247 | polysaccharide binding | F | 12 | 84 | 85 | 14.3 | 98.8 | 4.934 |
| 21 | 5021 | vascular endothelial growth factor receptor activity | F | 4 | 14 | 15 | 28.6 | 93.3 | 4.772 |
| 22 | 5539 | glycosaminoglycan binding | F | 11 | 81 | 82 | 13.6 | 98.8 | 4.516 |
| 23 | 8201 | heparin binding | F | 9 | 61 | 62 | 14.8 | 98.4 | 4.391 |
| 24 | 4714 | transmembrane receptor tyrosine kinase activity | F | 9 | 62 | 67 | 14.5 | 92.5 | 4.33 |
| 25 | 19838 | growth factor binding | F | 7 | 50 | 53 | 14.0 | 94.3 | 3.697 |
| 26 | 31012 | extracellular matrix | C | 45 | 255 | 268 | 17.6 | 95.1 | 11.453 |
| 27 | 5581 | collagen | C | 11 | 32 | 32 | 34.4 | 100.0 | 8.918 |
| 28 | 5604 | basement membrane | C | 13 | 44 | 45 | 29.5 | 97.8 | 8.804 |
| 29 | 5583 | fibrillar collagen | C | 3 | 9 | 9 | 33.3 | 100.0 | 4.564 |
GO types: biological processes (P), molecular functions (F) and cellular components (C). The Z-scores: calculated to identify the significant GO terms (Z-score ≥ 2.0, corresponding to P ≤ 0.05)