Table 4.
Top under-expressed Gene Ontology biological pathways associated mainly with down-regulated genes in RAC limbal epithelial progenitors
| GO ID | Gene Ontology (GO) Description | GO Type | Number of genes |
Z Score | |||||
|---|---|---|---|---|---|---|---|---|---|
| Down | Measured | in GO | % Down | %Present | |||||
| 1 | 30073 | insulin secretion | P | 3 | 7 | 7 | 42.9 | 100.0 | 7.752 |
| 2 | 30072 | peptide hormone secretion | P | 3 | 8 | 8 | 37.5 | 100.0 | 7.201 |
| 3 | 31124 | mRNA 3′-end processing | P | 3 | 9 | 9 | 33.3 | 100.0 | 6.742 |
| 4 | 6334 | nucleosome assembly | P | 9 | 73 | 117 | 12.3 | 62.4 | 6.350 |
| 5 | 79 | cyclin dependent protein kinase activity | P | 6 | 38 | 39 | 15.8 | 97.4 | 6.107 |
| 6 | 31497 | chromatin assembly | P | 9 | 82 | 126 | 11.0 | 65.1 | 5.852 |
| 7 | 46879 | hormone secretion | P | 3 | 12 | 13 | 25.0 | 92.3 | 5.716 |
| 8 | 5149 | interleukin-1 receptor binding | F | 5 | 12 | 12 | 41.7 | 100.0 | 9.856 |
| 9 | 5154 | epidermal growth factor receptor binding | F | 3 | 5 | 6 | 60.0 | 83.3 | 9.299 |
| 10 | 30353 | FGF receptor antagonist activity | F | 3 | 8 | 8 | 37.5 | 100.0 | 7.201 |
| 11 | 5152 | interleukin-1 receptor antagonist activity | F | 3 | 8 | 8 | 37.5 | 100.0 | 7.201 |
| 12 | 5104 | fibroblast growth factor receptor binding | F | 3 | 9 | 9 | 33.3 | 100.0 | 6.742 |
| 13 | 48019 | receptor antagonist activity | F | 3 | 10 | 10 | 30.0 | 100.0 | 6.351 |
| 14 | 30545 | receptor regulator activity | F | 3 | 11 | 11 | 27.3 | 100.0 | 6.013 |
| 15 | 19825 | oxygen binding | F | 4 | 29 | 35 | 13.8 | 82.9 | 4.562 |
| 16 | 5882 | intermediate filament | C | 11 | 80 | 107 | 13.8 | 74.8 | 7.563 |
| 17 | 786 | nucleosome | C | 9 | 68 | 104 | 13.2 | 65.4 | 6.665 |
| 18 | 43296 | apical junction complex | C | 6 | 55 | 56 | 10.9 | 98.2 | 4.752 |
GO types: biological processes (P), molecular functions (F) and cellular components (C). The Z-scores: calculated to identify the significant GO terms (Z-score ≥ 2.0, corresponding to P ≤ 0.05)