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Effects on clonidine 4-hydroxylation in HLM from addition of quinidine [CYP2D6 inhibitor (A)], furafylline [CYP1A2 inhibitor (B)], and ketoconazole [CYP3A inhibitor (C)]. Quinidine was evaluated across a broader range of clonidine substrate concentrations than furafylline or ketoconazole.
