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Parathion metabolites from male and female WT and CAR-null mice. HPLC was performed to quantify the formation of the toxic metabolite, paraoxon (POXON), and the nontoxic metabolite, PNP. A, paraoxon formation in male mice. B, PNP formation in male mice. C, paraoxon formation in female mice. D, PNP formation in female mice. *, significant difference between the two genotypes by Student's t test (p < 0.05).
