TABLE 2.

Differential toxicity of CAR-null mice compared with wild-type mice treated with 5 mg/kg/day parathion for 2 consecutive days

Data are shown as number of mice showing toxicity/number of mice treated.

Treatment	WT (M)	CAR-Null (M)	WT (F)	CAR-Null (F)
0 mg/kg/day	0/5	0/5	0/5	0/5
3 mg/kg TCPOBOP	0/4	0/5	0/4	0/5
5 mg/kg/day parathion	0/5*	4/4*	2/5*	5/5*
20 mg/kg/day parathion	4/4	4/4

M, male; F, female.

^* Statistical significance was assessed by Mann-Whitney rank-sum tests using toxicity rankings depending on the severity: 1 = not toxic; 2 = eye leakage; 3 = lethargy; slow movements or tremors; and 4 = death. Male and female data, p = 0.0079.