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CCG-63802 specifically binds to RGS4 and not to Gαo. A, purified RGS4 shows a dose-dependent change in melting temperature in the presence of CCG-63802 (EC50 ∼26 μM). B, a saturating concentration of CCG-63802 (100 μM) does not affect the melting temperature of Gαo. Data are presented as mean ± S.E.M. of three separate experiments.
