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CCG-63802 and CCG-63808 are reversible inhibitors of RGS4 (A) and RGS19 (B). CCG-4986 is an irreversible inhibitor of RGS4 and RGS19. In all cases, RGS-coated FCPIA beads were treated with 50 μM compound (or vehicle, DMSO) and then extensively washed. The beads were then split into two groups and tested for the ability to interact with Gαo-AF532 in the presence or absence of 50 μM compound. Data shown are the mean ± S.E.M. of three separate experiments.
