Fig. 6.

CCG-63802 is less sensitive to glutathione than other RGS4 inhibitors. A and B, CCG-63802 (A) and CCG-63808 (B) retain full inhibitory activity in the presence of 2 mM glutathione. The potency is right-shifted by approximately 0.5–1 Log (CCG-63802: Log IC₅₀ −5.25 ± 0.07 to −4.39 ± 0.07; CCG-63808: Log IC₅₀ −5.39 ± 0.06 to −4.68 ± 0.03). n = 2. C, in contrast, CCG-4986 loses more than two logs of potency (Log IC₅₀ −5.87 ± 0.03 to −3.66 ± 0.15) in the presence of glutathione. n = 3. Data presented as mean ± S.E.M.