Table 3.
SLC2A10 haplotype analysis for association with baseline, incident, and all PAD in type 2 diabetes.
| Haplotype Sequence | Frequency | Baseline PAD association | Incident PAD association | |||
|---|---|---|---|---|---|---|
| P* | OR (95% CI)* | P* | HR (95%CI)* | |||
| H1 | A3TAGCCTTTT | 0.051 | 0.87 | 1.28(0.07-22.8) | 0.89 | 1.17(0.13-10.4) |
| H2 | G3CTGTGCCCC | 0.499 | 0.01 | 0.20(0.05- 0.75) | 0.80 | 1.20(0.30- 4.72) |
| H3 | G2TAGCCTTTT | 0.118 | 0.08 | 4.20(0.82- 21.6) | 0.29 | 0.42(0.09- 2.06) |
| H4 | G3TAGCCTTTT | 0.063 | 0.03 | 14.5(1.3-160) | 0.007 | 6.78(1.66- 27.6) |
| H5 | G2CAACCTTTT | 0.041 | 0.97 | 1.07(0.04- 29.5) | 0.99 | 1.8 × 10-7 (0-∞) |
| H6 | G2CTGTGCCCC | 0.026 | 0.42 | 5.4 × 10-4(0- 40159) | 0.66 | 0.60(0.06-5.99) |
| H7 | G3TAGCCTTTC | 0.023 | 0.48 | 1.7 × 10-6 (0-∞) | 0.87 | 1.22(0.10- 14.5) |
| H8 | G3CTGTGCCCT | 0.015 | 0.40 | 7.67(0.07- 894) | 0.34 | 3.01(0.31- 29.0) |
| Rare haplotypes | 0.15 | 0.26 | 1.36(0.80-2.31) | 0.99 | 4.8 × 10-6 (0-∞) | |
* P-values, odds ratios, and hazard ratios were adjusted for covariates including age, sex, duration of diabetes, body mass index, triglyceride, total cholesterol, hemoglobin A1C, systolic blood pressure and current smoking status.
PAD, peripheral artery disease; OR, odds ratio; HR, hazard ratio, CI, confidence interval