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. 2010 Aug 23;8:21. doi: 10.1186/1477-3155-8-21

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Copyright ©2010 Walter et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Detection of PSMA in human prostate cancer tissue. Detection of PSMA positive structures in prostate cancer tissue sections by immunohistochemical staining using anti-PSMA aptamer (PSMA apt)-conjugated AuNPs. As a negative control, AuNPs conjugated with miniStrep aptamer (miniStrep apt) were used. A polyclonal antibody directed against PSMA (PSMA pAb) was used as a positive control. Positive control was additionally stained with Haematoxylin and Eosin. Black arrows indicate specific staining, while white arrows flag unspecific binding.