Table 7.
Summary of the properties of AMA1 epitopes
| Epitope | HLA-restriction | Amino acids | Sequence | Location | Crystal face |
Accessibility |
|---|---|---|---|---|---|---|
| E1 | B44 | 13-21 | FEFTYMINF | Signal | ||
| E2 | B44 | 35-44 | SDVYRPINEH | Prodomain | ||
| E3 | B08 | 47-55 | HPKEYEYPL | Prodomain | ||
| E4 | B44 | 51-59 | YEYPLHQEH | Prodomain | ||
| E5 | B08 | 175-183 | YLKDGGFAF | Domain I | F/B | YnaKD |
| E6 | A01 | 194-202 | TLDE+MRHFY | Domain I | B | D, E, H, F |
| E7 | A01 | 198-207 | MRHFYKDNKY | Domain I | F/B | H, F, D, K, Y |
| E8 | B44 | 327-335 | NEFPAIDLF | Domain II | F/B | E, P, I |
| E9 | A02 | 339-346 | KLVFELS*A | Domain II | F | E, L |
| E10 | A01 | 389-397 | RYKSHGKGY | Domain II | F | H, K, Y |
| E11 | A02 | 405-414 | ETQKCEIFNV | Domain II | B | E, T, Q, N |
| E12 | A02 | 406-414 | TQKCEIFNV | Domain II | F | T, Q, N |
| E13 | A02 | 410-419 | EIFNVK*PTCL | Domain II | F | NK |
| E14 | B44 | 520-528 | NEVVVKE*EY | Domain III | F | VEE |
Variable amino acids are highlighted in bold.
*Indicated that there is only one variant of <0.001% frequency
E+ is essential for binding of growth inhibitory MAb 1F9
F = front, B = back, F/B = wraps from front to back
Yna Accessibility not available for amino acid Y
Confirmed epitope numbers are indicated in bold