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IVM antagonizes the effects of a behaviorally relevant concentration of ethanol in P2X4Rs. Exposure to 0.5 μM IVM eliminated the significant inhibitory effect of 25 mM ethanol on EC10 ATP-gated currents in WT P2X4Rs. Data are presented as mean ± S.E.M. of 8 to 10 oocytes per data point. *, P < 0.05 compared with ATP control.
