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. 2010 Sep;334(3):720–728. doi: 10.1124/jpet.110.167908

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Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

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Fig. 6. — The effects of IVM and hexanol on ATP-gated currents in P2X4Rs are nonadditive. A, IVM (3 μM) and hexanol (10 mM) significantly potentiated ATP-induced currents when applied individually or in combination. P < 0.05 compared with ATP only. B, representative tracings showing modulation of ATP-induced currents by individual applications of IVM (3 μM), hexanol (10 mM), and coapplication of IVM and hexanol. Horizontal short bars above the currents depict ATP or drug applications. Numbers next to the short bars represent hexanol concentration. Dotted line represents the baseline responses for ATP. C, comparison of experimentally obtained data of the combined effects of IVM and hexanol (filled bar) and estimated additive value of the effects of individual drugs (empty bar) shows a significant difference. **, P < 0.01. Data in A and C are presented as mean ± S.E.M. of three to five oocytes per data point.