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. 2010 Sep;334(3):761–774. doi: 10.1124/jpet.110.168211

TABLE 1.

Agonist and antagonist study on human nAChRs

	Hα4β2 nAChRs		Hα3β4 nAChRs
	EC₅₀ or IC₅₀ Value^a	n_H	EC₅₀ or IC₅₀ Value^a	n_H
Epibatidine (EC₅₀)	18.1 (6.5–50.6) nM	0.6	37.4 (10.7–71.4) nM	0.9
Nicotine (EC₅₀)	8.9 (5.7–13.9) μM	1.2	9.1 (4.5–18.6) μM	0.9
d-tubocurarine (IC₅₀)	2.3 (1.9–3.9) μM	−0.7	1.6 (0.4–3.5) μM	−0.9
Mecamylamine (IC₅₀)	0.5 (0.3–0.8) μM	−0.9	0.2 (0.1–0.3) μM	−0.8
KAB-18 (IC₅₀)	13.5 (9.7–18.5) μM	−0.7	NA

n_H, Hill coefficient; NA, no activity at concentrations up to 100 μM.

^a

Values represent geometric means (confidence limits), n = 4–8.