Fig. 5.

Pretreatment of the guinea pigs with galantamine prevented soman-induced changes in the frequency and amplitude of IPSCs. Animals were treated with galantamine (8 mg/kg i.m.) and 30 min later they were challenged with 1×LD₅₀ soman (26.3 μg/kg s.c.). Hippocampal slices were obtained from animals at 1 h, 24 h, or 6 to 9 days after the soman challenge. Graphs show frequency (A) and amplitudes (B) of IPSCs in galantamine-treated, soman-challenged animals were comparable with control levels. Graph and error bars represent mean and S.E.M., respectively, of results obtained from the following number of neurons: 30 (saline), 12 (1 h after soman), 13 (24 h after soman), and 10 (6–9 days after soman).