Fig. 4.

Food intake was acutely decreased in nondiabetic and db/db mice that had been previously conditioned for 5 days to eat for 1 h daily, and postprandial glucose levels were blunted by GLP-1-Tf. A and B, blood glucose and food intake in nondiabetic mice measured during the time intervals shown after IP GLP-1-Tf and Tf at time 0. C and D, blood glucose and food intake in db/db mice measured during the time intervals shown after intraperitoneal GLP-1-Tf, Tf, and EX-4 at time 0. Values are expressed as means ± S.E., n = 5 animals per treatment group. *, p < 0.05, compared with hTf-treated animals alone.