TABLE 3.
Estimated pharmacokinetic and pharmacodynamic parameters for RET and RBC baselines
| Parameter (unit) | Definition | Estimate | CV% |
|---|---|---|---|
| RETMin (104 cell/μl) | Minimum value for RET baseline | 9.07 | 37.3 |
| RETMax (104 cell/μl) | Maximum value for RET baseline | 20.13 | 1.69 |
| T1/2-RET (days) | Age1/2 of animals past since the beginning of the study for RET baseline change | 48.04 | 10.4 |
| hRET | Hill coefficient for RET | 4.95 | 46.5 |
| RBCMin (106 cell/μl) | Minimum value for RBC baseline | 7.42 | 0.32 |
| RBCMax (106 cell/μl) | Maximum value for RBC baseline | 8.14 | 3.79 |
| T1/2-RBC (days) | Age1/2 of animals past since the beginning of the study for RBC baseline change | 46.6 | 13.9 |
| hRBC | Hill coefficient for RBC | 3.85 | 72.8 |