Fig. 11.

Correlation between plasma androstanediol levels and seizure protection in the kindling model. A, plasma androstanediol levels after various doses of androstanediol (from Fig. 10) were plotted against kindling seizure protection values from experiment in Fig. 6A. The data points were fit with a logistic function (EC₅₀ = 3.1 μg/ml). B, similar analysis from the sedative/motor toxicity experiment in Fig. 9 (EC₅₀ = 29 μg/ml).