TABLE 1.
Antiseizure ED50 values of androstanediol in mouse models of epilepsy
Values in parentheses are 95% confidence limits.
| Seizure Model | ED50 | Reference |
|---|---|---|
| mg/kg | ||
| Kindling model | ||
| Hippocampus kindling | 50 (36–64) | This study |
| GABAA receptor antagonists | ||
| Pentylenetetrazol | 40 (27–60) | Reddy (2004b) |
| Bicuculline | 44 (24–81) | Reddy (2004a) |
| Picrotoxin | 39 (21–74) | Reddy (2004a) |
| Glutamate receptor agonists | ||
| Kainic acid | >200 (N.D.) | Reddy (2004a) |
| N-Methyl-d-aspartate | >200 (N.D.) | Reddy (2004a) |
| 4-Aminopyridine | >200 (N.D.) | Reddy (2004a) |
| Status epilepticus model | ||
| Pilocarpine | 81 (45–143) | D.S. Reddy, unpublished data |
| Electroshock models | ||
| Maximal electroshock | N.D. | |
| 6 Hz | N.D. |
N.D., not determined.