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. Author manuscript; available in PMC: 2011 Sep 7.
Published in final edited form as: Biochemistry. 2010 Sep 7;49(35):7674–7682. doi: 10.1021/bi100973m

FIGURE 5. Secondary structure predictions.

FIGURE 5

Secondary structure predictions for the mostly α-helical domain and mixed α/β ADPRT catalytic domain of hPARP-1 (A) and hPARP-2 (B) are shown adjacent to their respective crystal structures (Protein Data Bank Identification numbers 2RCW and 3KJD for hPARP-1 and hPARP-2, respectively) and are compared to that of hPARG59 (C). The ADPRT catalytic domain of PARP-1 and PARP-2 and the ADPRT-like catalytic domain C of PARG are aligned to show structural similarity. The α-helices and β-sheets are indicated and β-sheet 5, containing the catalytic glutamate residues of each enzyme, is labeled by a red square. The predictions were carried out using the PHD and PROFsec algorithms as described in Materials and Methods.