Table 3.

Abnormality in FISH, defined as 2 or more markers abnormal among the 4 tested markers, by time between sputum collection and the date of lung cancer incidence, by cancer histology, and by cancer stage.

Characteristic	Cases		Odds ratio (95% CI) *
	n / N abnormal	%	Age-adjusted model	Fully-adjusted model**
					Time between sputum collection and lung cancer incidence
More than 18 months	14/45	31	2.0 (0.7, 5.6)	1.7 (0.6, 5.3)
Within 18 months	42/55	76	24.1 (8.8, 65.8)	29.9 (9.5, 94.1)
Among samples collected within 18 months before diagnosis
Lung cancer histology
Squamous cell	15/16	94	131.1 (13.6, 999)	Not estimable
Adenocarcinoma	11/17	65	12.9 (3.6, 46.2)	16.4 (3.7, 72.2)
Small cell	3/5	60	10.2 (1.4, 73.7)	4.7 (0.2, 99.9)
Others	10/13	77	29.8 (6.0, 148.8)	77.8 (7.9, 764.5)
Unknown	3/4	75	21.0 (1.7, 254.4)	10.3 (0.4, 242.4)
Lung cancer stage
Localized	14/15	93	123.5 (12.4, 999)	Not estimable
Regional	4/7	57	12.2 (2.0, 73.5)	15.7 (2.1,118.6)
Distant	8/14	57	9.0 (2.4, 34.7)	20.6 (3.6, 118.0)
Unknown	16/19	84	39.8 (9.1, 173.4)	37.7 (7.6, 186.8)

^*Odds ratios comparing cases to the pooled control group, among whom there were 7/59 (12%) who had ≥ 2 abnormal FISH markers for ≤ 18 month proximal samples and 7/37 (19%) who had ≥ 2 abnormal FISH markers for > 18 month proximal samples.

^**Adjusted for age, sex, FEV1, pack-years of smoking, and current smoking status