Table 4.

Comparison of CA FISH findings in this analysis with previously-published findings for sputum cytology and sputum DNA methylation markers from this same cohort.

	Sensitivity	Specificity	Fully-adjusted odds ratio (95% CI)
Cytologic atypia*	29%	83%	1.8 (1.3, 2.6)
DNA methylation**	64%	64%	6.5 (1.2, 35.5)
CA-FISH ***	76%	85%	29.9 (9.5, 94.1)

^*from reference # 15. Atypia is defined as moderate atypia or worse. Odds ratio is adjusted for age, sex, race/ethnicity, pack-years of smoking, and smoking status at baseline, and year of enrollment into the cohort.

^**From reference # 18. Methylation is defined as three or more of a panel of six markers methylated. Odds ratio is adjusted for age, sex, fev1, pack-years of smoking, and current smoking status

^***Data from the current report. Positive FISH assay is defined as 2 or more of 4 FISH markers abnormal. Odds ratio is adjusted for age, sex, FEV1, pack-years of smoking, and current smoking status