FIGURE 5.

Graphic representation of daily bleeding records from vaginal smears that are used to determine ovarian cycle duration in the cynomolgus monkey. The data correspond to those shown in Figure 15 (animals la and 2a). X-axis denotes days, and y-axis denotes the number of cycles. Grey boxes indicate bleeding. Black boxes aid in cycle determination by denoting the number of days for every month. Cycle duration is determined by the interval between first day of bleeding and last day prior to onset of next bleeding. Note that animal la maintained a rather constant cycle duration (26–31 days), whereas its companion, animal 2a, showed cycle irregularity (increased cycle length up to 52 days or lack of cyclicity) during pair housing. Cyc. = cycle duration in days; P = shift from single to pair housing; SD = start of dosing; DS = dosing stopped.