Table 2. Clinical features, response and toxicity.
|
Response
|
Haematologic toxicity
|
Non-haematologic toxicity
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| N=149 | N (%) | OR (95% CI) | P* | N (%) | OR (95% CI) | P* | N (%) | OR (95% CI) | P* |
| Gender | |||||||||
| Male | 53 (58.9) | 1 | 0.8 | 19 (21.1) | 1 | 0.85 | 35 (38.9) | 1 | 0.6 |
| Female | 32 (57.1) | 1.07 (0.6–2.1) | 13 (22.4) | 1.08 (0.49–2.4) | 20 (34.5) | 0.83 (0.42–1.65) | |||
| Primary tumour | |||||||||
| Colon | 26 (49.1) | 1 | 0.076 | 9 (17) | 1 | 0.4 | 22 (41.5) | 1 | 0.52 |
| Rectum | 59 (64.1) | 0.54 (0.27–1.07) | 22 (23.4) | 1.5 (0.63–0.35) | 34 (36.2) | 0.8 (0.4–1.6) | |||
| ECOG | |||||||||
| 0 | 50 (58.8) | 1 | 0.7 | 20 (23.4) | 1 | 0.81 | 36 (42.4) | 1 | 0.28 |
| 1 | 32 (57.1) | 1.07 (0.54–2.1) | 11 (23.5) | 0.76 (0.33–1.7) | 18 (31) | 0.61 (0.3–1.24) | |||
| 2 | 2 (40) | 2.1 (0.3–13.5) | 1 (19) | 0.81 (0.09–7.6) | 1 (20) | 0.34 (0.036–3.2) | |||
| Number of cycles | |||||||||
| ⩽3 | 16 (43.2) | 1 | 0.038 | 7 (17.9) | 1 | 0.53 | 14 (35.9) | 1 | 0.8 |
| >3 | 69 (62.7) | 0.45 (0.2–0.97) | 25 (22.7) | 1.35 (0.65–0.35) | 42 (38.2) | 1 (0.52–2.4) | |||
| Number of lesions | |||||||||
| ⩽3 | 45 (54.2) | 1 | 0.31 | 20 (23.5) | 1 | 0.48 | 36 (42.4) | 1 | 0.17 |
| >3 | 40 (62.5) | 0.71 (0.37–1.4) | 12 (18.8) | 0.75 (0.34–1.7) | 20 (31.2) | 0.62 (0.3–1.22) | |||
| Tumour differentiation | |||||||||
| Well | 29 (69) | 1 | 0.023 | 11 (26.2) | 1 | 0.4 | 16 (38) | 1 | 0.01 |
| Moderate | 46 (57) | 1.7 (0.77–3.7) | 17 (21) | 0.75 (0.3–1.8) | 37 (45.7) | 1.4 (0.64–2.9) | |||
| Poor | 3 (25) | 6.7 (1.6–28.8) | 1 (18.3) | 0.26 (0.03–2.2) | 0 | 0.62 (0.49–0.79) | |||
| Age (years) | |||||||||
| ⩽65 | 44 (33) | 1 | 0.2 | 16 (19) | 1 | 0.4 | 22 (26) | 1 | 0.001 |
| >65 | 41 (64) | 0.63 (0.32–1.24) | 16 (24) | 1.4 (0.63–3.04) | 34 (52) | 3.09 (1.55–6.1) | |||
Abbreviations: CI=confidence interval; OR=odds ratio.
*P-values correspond to χ2-test or Fisher's exact test, when appropriate.