Table 3. Genotypes, haplotypes and response to treatment.
| Polymorphism | Genotype | R (%) | NR (%) | OR (95% CI) | P † |
|---|---|---|---|---|---|
| 3TRP/3TRP | 19 (40) | 28 (60) | 1.00 | ||
| TS 5′TRP | 2TRP/3TRP | 43 (61) | 27 (39) | 0.43 (0.20–0.91) | 0.0024 |
| 2TRP/2TRP | 23 (79) | 6 (21) | 0.18 (0.06–0.52) | ||
| Ins/ins | 43 (62) | 26 (38) | 1.00 | ||
| TS 3′UTR | Ins/del | 36 (55) | 30 (45) | 1.38 (0.69–2.74) | 0.56 |
| Del/del | 6 (50) | 6 (50) | 1.65 (0.48–5.67) | ||
| *1/*1 | 31 (55) | 25 (45) | 1.00 | ||
| UGT1A1*28 | *1/*28 | 47 (61) | 30 (39) | 0.79 (0.39–1.59) | 0.67 |
| *28/*28 | 7 (50) | 7 (50) | 1.24 (0.38–4.01) | ||
| *1/*1 | 33 (60) | 22 (40) | 1.00 | ||
| UGT1A9*22 | *1/*22 | 34 (53) | 30 (47) | 1.32 (0.64–2.74) | 0.56 |
| *22/*22 | 18 (64) | 10 (36) | 0.83 (0.32–2.14) | ||
| *1/*1 | 16 (64) | 9 (36) | 1.00 | ||
| *1/*2 | 10 (50) | 10 (50) | 1.8 (0.5–5.9) | ||
| UGT1A7 | *1/*3 | 5 (71.4) | 2 (28.6) | 0.7 (0.1–4.4) | 0.9 |
| *2/*2 | 26 (55.3) | 21 (44.7) | 1.4 (0.5–3.9) | ||
| *2/*3 | 16 (57.1) | 12 (42.9) | 1.3 (0.4–4) | ||
| *3/*3 | 12 (60) | 8 (40) | 1.2 (0.4–4) | ||
|
UGT1A Haplotypesa
|
OR (95% CI)
|
P | |||
| I | 1 | ||||
| II | 1.65 (0.69–3.95) | 0.17 | |||
| III | 0.73 (0.37–1.46) | ||||
| VII | 0.88 (0.48–1.64) | ||||
Abbreviations: CI=confidence interval; NR=no response; OR=odds ratio; R=response.
a
Only haplotypes with a frequency >0.05 were considered. †P-values correspond to χ2-test or Fisher's exact test, when appropriate.