Table 4. Logistic regression analysis.
| Outcome | OR (95% CI) | P |
|---|---|---|
| Response rate | ||
| TS 3TRP/3TRP (ref. 2TRP/2TRP) | 5.87 (1.68–20.45) | 0.005 |
| Poor differentiation (ref. well) | 8.84 (1.79–43.56) | 0.007 |
| Number of cycles ⩽3 | 2.44 (1.02–5.88) | 0.046 |
| Severe haematologic toxicity | ||
| UGT1A1*28/*28 (ref. *1/*28 and *1/*1) | 6.27 (1.09–36.12) | 0.040 |
| Severe non-hematologic toxicity | ||
| UGT1A9*1/*1 (ref. *1/*22 and *22/*22) | 2.70 (1.07–6.82) | 0.035 |
| Older than 65 | 3.23 (1.44–7.14) | 0.004 |
| Neutropenia | ||
| UGT1A1*28/*28 (ref. *1/*28 and *1/*1) | 6.40 (1.11–37.03) | 0.038 |
| Neutropenia and diarrhoea | ||
| UGT1A1*28/*28 (ref. *1/*28 and *1/*1) | 18.87 (2.14–166.67) | 0.008 |
| Diarrhea first cycle | ||
| UGT1A1*28/*28 (ref. *1/*28 and *1/*1) | 23.80 (2.05–250) | 0.011 |
| UGT1A9*1/*1 (ref. *1/*22 and *22/*22) | 3.24 (0.99–10.63) | 0.053 |
| UGT1A7*3/*3 (ref. other) | 27.64 (1.58–482.86) | 0.023 |
Abbreviations: CI=confidence interval; OR=odds ratio; ref=reference category/categories.