Table 5. UGT1A genotypes, haplotypes and toxicity.

		Haematologic			No haematologic			Neutropenia			Diarrhoea			Neutropenia and diarrhoea
Gene	Genotype	Yes (%)	OR (95% CI)	P	Yes (%)	OR (95% CI)	P	Yes (%)	OR (95% CI)	P	Yes (%)	OR (95% CI)	P	Yes (%)	OR (95% CI)	P
First cycle
UGT1A1	*28/*28	2 (13.3)	2.14 (0.42–10.86)	0.31	6 (40)	4.92 (1.55–15.64)	0.004	1 (6.7)	1.13 (0.13–9.67)	1	4 (26.7)	3.7 (1.02–13.42)	0.036	—	—	—
	Other	9 (6.7)	1		16 (11.9)	1		8 (6)	1		12 (9)	1		—	—
UGT1A9	*1/*1	3 (5.3)	1	0.44	12 (11.9)	1	0.09	2 (3.5)	1	0.5	9 (15.8)	1	0.1	—	—	—
	Other	8 (8.7)	1.71 (0.44–6.75)		10 (21.1)	0.46 (0.18–1.14)		7 (7.6)	2.3 (0.45–11.3)		7 (7.6)	0.44 (0.15–1.25)		—	—
UGT1A7	*3/*3	2 (9.1)	1.31 (0.26–6.52)	0.74	4 (10.9)	1.35 (0.41–4.44)	0.63	8 (4.5)	0.71 (0.08–5–96)	1	2 (9.1)	0.81 (0.17–3.83)	1	—	—	—
	Other	9 (7.1)	1		18 (18.2)	1		1 (6.3)	1		14 (11)	1		—	—
All UGTs	No favourable*	2 (18.2)	3.19 (0.6–17)	0.16	4 (36.4)	3.8 (1.01–14.33)	0.036	1 (9.1)	1.63 (0.18–14.32)	0.5	2 (18.2)	1.97 (0.39–10.03)	0.33	—	—	—
	Other	9 (6.5)	1		18 (13)	1		8 (5.8)	1		14 (10.1)	1		—	—
All UGTs	Favourable	8 (8.9)	1	0.53	9 (10)	1	0.043	7 (7.8)	1	0.32	6 (6.7)	1	0.047	—	—	—
	Other	3 (5.1)	0.55 (0.14–2.16)		13 (22)	2.54 (1.01–6.41)		2 (3.4)	0.42 (0.08–2.08)		10 (16.9)	2.86 (0.98–8.34)		—	—
Haplotypes
I		—	1	—	—	1	—	—	1	—	—	1	—	—	—	—
II		—	NA	NA	—	0.33 (0.04–2.61)	0.29	—	—	—	—	0.46 (0.06–3.72)	0.47	—	—	—
III		—	0.39 (0.08–1.81)	0.23	—	1.54 (0.61–3.88)	0.36	—	0.45 (0.10–2.06)	0.30	—	1.57 (0.56–4.38)	0.39	—	—	—
VII		—	1.27 (0.48–3.38)	0.63	—	2.5 (1.08–5.81)	0.03	—	0.93 (0.32–2.72)	0.89	—	1.98 (0.76–5.13)	0.60	—	—	—
End of treatment
UGT1A1	*28/*28	6 (40)	2.77 (0.91–8.47)	0.065	10 (66.7)	3.83 (1.23–11–86)	0.014	6 (40)	2.91 (0.95–8.92)	0.05	9 (60)	4.08 (1.36–12.28)	0.008	5 (33.3)	12.7 (3.14–51.34)	<0.0001
	Other	26 (19.4)	1		46 (34.3)	1		25 (18.7)	1		36 (26.9)	1		5 (3.8)	1
UGT1A9	*1/*1	10 (17.5)	1	0.36	29 (50.9)	1	0.008	10 (17.5)	1	0.44	24 (42.1)	1	0.013	5 (8.9)	1	0.4
	Other	22 (23.9)	1.48 (0.64–3.4)		27 (29.3)	0.4 (0.2–0.8)		21 (22.8)	1.39 (0.6–3.2)		21 (22.8)	0.41 (0.2–0.8)		5 (5.5)	0.6 (0.16–2.15)
UGT1A7	*3/*3	5 (22.7)	1.09 (0.37–3.22)	0.88	12 (54.5)	2.26 (0.91–5.65)	0.075	5 (22.7)	1.14 (0.39–3.39)	0.81	11 (50)	2.74 (1.09–6.89)	0.028	4 (18.2)	4.41 (1.13–17.15)	0.022
	Other	27 (21.3)	1		44 (34.6)	1		26 (20.5)	1		34 (26.8)	1		6 (4.8)	1
All UGTs	No favourable*	5 (45.5)	3.4 (0.97–12.1)	0.044	8 (72.7)	5 (1.27–19.72)	0.02	5 (45.5)	3.59 (1.02–12.67)	0.036	7 (63.6)	4.61 (1.28–16–63)	0.018	4 (36.4)	12.38 (2.83–54.18)	<0.0001
	Favourable	27 (19.6)	1		48 (34.8)	1		26 (18.8)	1		38 (27.5)	1		6 (4.4)	1
All UGTs	Favourable	21 (21.3)	1	0.5	26 (28.9)	1	0.007	20 (22.2)	1	0.6	20 (22.2)	1	0.009	4 (4.5)	1	0.19
	Other	11 (18.6)	0.75 (0.33–1.71)		30 (50.8)	2.55 (1.29–5.05)		11 (18.6)	0.8 (0.35–1.83)		25 (42.4)	2.57 (1.26–5.27)		6 (10.3)	2.45 (0.66–9.1)
Haplotypes
I		—	1	—	—	1	—	—	1	—	—	1	—	—	1
II		—	0.16 (0.02–1.24)	0.08	—	1.29 (0.53–3.16)	0.58	—	0.16 (0.02–1.24)	0.08	—	1.27 80.48–3.32)	0.63	—
III		—	0.58 (0.23–1.43)	0.24	—	1.58 (0.81–3.11)	0.18	—	0.55 (0.22–1.36)	0.2	—	1.31 (0.63–2.71)	0.47	—
VII		—	1.50 (0.76–2.98)	0.25	—	2.11 (1.12–3.98)	0.02	—	1.52 (0.76–3.03)	0.23	—	2.24 (0.63–7.24)	0.02	—

Abbreviations: CI=confidence interval; NA=not applicable; OR=odds ratio;

Note: All reported P-values correspond to χ²-test or Fisher's exact test, when appropriate.

No favourable UGT1A genotypes=UGT1A1^*28/^*28, UGT1A7^*3/^*3 and UGT1A9^*1/^*1.