Table 2.
Association between lower percentile of weight, height, absolute CD4 count, and CD4% gains at 6 months of ART and time to death, virological suppression, and treatment failure in a cohort of 1394 HIV-infected children from Soweto, South Africa
| Time to Death after 6 months | Time to Viral suppression** | Time to Treatment Failure£ | ||||
|---|---|---|---|---|---|---|
| HR (95%Confidence Interval) |
HR (95%Confidence Interval) |
HR (95%Confidence Interval) |
||||
| crude | Adjusted* | crude | adjusted† | crude | adjusted‡ | |
|
Weight | ||||||
| 3rd | 8.32 (2.32, 29.84) | 6.45 (1.69, 24.61) | 0.71 (0.52, 0.98) | 0.66 (0.48, 0.97) | 1.83 (0.75, 4.51) | 2.56 (1.04, 6.32) |
| 10th | 6.04 (2.02, 18.04) | 6.70 (2.15, 20.08) | 0.83 (0.68, 1.02) | 0.78 (0.63, 0.98) | 1.57 (0.86, 2.85) | 1.84 (1.00, 3.38) |
| 25th | 3.60 (1.26, 10.27) | 5.07 (1.68, 15.23) | 0.86 (0.75, 0.99) | 0.83 (0.71, 0.96) | 1.21 (0.80, 1.83) | 1.31 (0.86, 2.01) |
| 33rd | 2.85 (0.99, 8.21) | 4.09 (1.32, 12.74) | 0.83 (0.73, 0.94) | 0.80 (0.70, 0.91) | 1.44 (1.00, 2.07) | 1.56 (1.07, 2.28) |
| 50th | 2.38 (0.75, 7.59) | 3.07 (0.93, 10.12) | 0.87 (0.78, 0.98) | 0.84 (0.74, 0.95) | 1.30 (0.89, 1.84) | 1.47 (1.01, 2.16) |
|
Height | ||||||
| 3rd | 1.62 (0.21, 12.38) | 1.88 (0.24, 14.57) | 1.00 (0.77, 1.30) | 0.97 (0.74, 1.29) | 0.15 (0.02, 1.06) | 0.22 (0.03, 1.55) |
| 10th | 2.76 (0.87, 8.81) | 2.34 (0.72, 7.67) | 1.08 (0.91, 1.28) | 1.01 (0.84, 1.21) | 0.81 (0.49, 1.36) | 0.84 (0.49, 1.44) |
| 25th | 1.36 (0.46, 4.07) | 1.39 (0.45, 4.24) | 1.08 (0.95, 1.23) | 1.03 (0.89, 1.17) | 0.74 (0.49, 1.11) | 0.73 (0.48, 1.13) |
| 33rd | 1.25 (0.43, 3.61) | 1.30 (0.44, 3.88) | 1.08 (0.96, 1.22) | 1.03 (0.91, 1.17) | 0.77 (0.53, 1.12) | 0.76 (0.51, 1.13) |
| 50th | 1.72 (0.58, 5.12) | 2.22 (0.68, 7.26) | 1.05 (0.93, 1.18) | 0.99 (0.87, 1.12) | 0.75 (0.52, 1.07) | 0.75 (0.51, 1.10) |
|
CD4 count | ||||||
| 3rd | 0.61 (0.22, 1.68) | 0.42 (0.15, 1.20) | 0.84 (0.59, 1.20) | 0.86 (0.58, 1.28) | 0.48 (0.07, 3.44) | - |
| 10th | 3.74 (1.04, 13.42) | 5.40 (1.46, 20.00) | 0.57 (0.45, 0.72) | 0.54 (0.42, 0.69) | 3.37 (2.01, 5.64) | 3.42 (1.96, 5.99) |
| 25th | 3.57 (1.25, 10.19) | 3.89 (1.29, 11.71) | 0.75 (0.65, 0.87) | 0.75 (0.64, 0.88) | 1.57 (1.07, 2.31) | 1.78 (1.18, 2.69) |
| 33rd | 2.95 (1.02, 8.49) | 3.03 (1.01, 9.11) | 0.80 (0.70, 0.91) | 0.79 (0.69, 0.92) | 1.43 (0.99, 2.05) | 1.56 (1.06, 2.30) |
| 50th | 1.59 (0.53, 4.73) | 1.51 (0.49, 4.66) | 0.92 (0.81, 1.04) | 0.90 (0.79, 1.03) | 1.21 (0.84, 1.75) | 1.23 (0.82, 1.83) |
|
CD4 count Percentage | ||||||
| 3rd | 11.01 (3.07, 39.50) | 19.43 (4.88, 77.38) | 0.52 (0.35, 0.77) | 0.50 (0.32, 0.78) | 7.00 (3.51, 13.96) | 8.75 (3.93, 19.48) |
| 10th | 8.31 (2.88, 23.97) | 9.11 (3.03, 27.34) | 0.65 (0.52, 0.81) | 0.59 (0.47, 0.76) | 4.28 (2.70, 6.80) | 4.40 (2.68, 7.23) |
| 25th | 3.48 (1.22, 9.91) | 4.31 (1.44, 12.88) | 0.75 (0.65, 0.87) | 0.73 (0.62, 0.85) | 2.75 (1.92, 3.95) | 2.73 (1.85, 4.04) |
| 33rd | 2.28 (0.80, 6.50) | 2.60 (0.87, 7.74) | 0.75 (0.66, 0.86) | 0.73 (0.63, 0.84) | 2.39 (1.67, 3.41) | 2.43 (1.66, 3.57) |
| 50th | 1.20 (0.42, 3.45) | 1.11 (0.37, 3.31) | 0.82 (0.73, 0.93) | 0.81 (0.71, 0.92) | 1.57 (1.07, 2.28) | 1.57 (1.05, 2.34) |
Adjusted for Baseline WHO clinical stage, Baseline weight-for-age z score (WAZ), and TB treatment at ART initiation.
Adjusted for age for weight and height, baseline WHO clinical stage and age for CD4 count and CD4 percentage.
Adjusted for baseline WHO clinical stage and severity of immunosuppression for weight and height, baseline WHO clinical stage and WAZ for CD4 cell count and CD4%.
Viral load < 400 HIV RNA copies/ml,
2 viral load > 1000 after initial suppression or never suppress or > 1 year follow without viral suppression and regimen change