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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Cancer Res. 2010 Jan 12;70(2):609–620. doi: 10.1158/0008-5472.CAN-09-2327

Figure 1.

Figure 1

(A) Relative response of 30 colon carcinoma cell lines to HDACi-induced apoptosis. Cells lines were treated with 1, 5 or 10 mM butyrate for 72 hours (Mean±SEM, n=3). (B). Clonogenic survival of sensitive and resistant lines following 24h HDACi treatment (n=3–4). (C). Response of 2 sensitive and 2 resistant cell lines to VPA treatment in vivo. (D) Quantitation of colony formation shown in panel (C). Values shown are mean±SEM percentage colony formation following 5 mM butyrate treatment relative to control for the sensitive and resistant cell lines. (E). Quantitation of tumor size following HDACi treatment in vivo (n=4–5, *P<0.05).