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(A) Silencing efficiency of Sp1 and Sp3 protein expression. (B-C) Silencing of Sp1 and Sp3 in HCT116 cell partially attenuates HDACi-induced apoptosis at 24h as assessed by (B) sub-diploid DNA content and (C) PARP cleavage, and (D-F) HDACi-induced transcriptional response.
