Table 2.
Longitudinal QTc Interval Assessments at Baseline Two, Four, and Eight Weeks
| Baseline (n = 100) | 2 week (n = 64) | 4 week (n = 39) | 8 week (n = 28) | |
|---|---|---|---|---|
| Median methadone dose in mg (Q1–Q3) | — | 23 (10–30) | 15 (10–23) | 28 (11–38) |
| Mean QTc in ms (SD) | 427 (27) | 430 (22) | 375 (41) | 373 (41) |
| Median QTc in ms (Q1–Q3) | 430 (411–444) | 431 (421–441) | 380 (344–404) | 380 (341–396) |
| QTc >ULNa | 28 (28%) | 20 (31%) | 3 (8%) | 3 (11%) |
| QTc >500 ms | 0 (0%) | 1 (2%) | 0 (0%) | 0 (0%) |
| QTc >10% above baseline | — | 5 (8%) | 1 (3%) | 1 (4%) |
| QTc >25% above baseline | — | 0 (0%) | 0 (0%) | 0 (0%) |
a
QTc >430 for males and >450 for females.
SD, standard deviation; ULN, upper normal limit.