Table 4.

Differences in Methadone Dose and QTc Interval at Two Weeks between Patients with and without Baseline QT Prolongation

	No baseline QTc prolongation (n = 47)	Baseline QTc prolongation (n = 17)	p value
Median methadone dose in mg (Q1–Q3)	21 (10–30)	20 (10–34)	0.56
Mean QTc in ms (SD)	426 (18)	440 (28)	0.063
Median QTc in ms (Q1–Q3)	429 (420–435)	435 (425–451)	0.042
QTc > ULN	8 (17%)	12 (71%)	<0.001
QTc > 500	0 (0%)	1 (6%)	0.094
QTc > 10% above baseline	4 (9%)	1 (6%)	0.73
QTc > 25% above baseline	0 (0%)	0 (0%)	—