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. 2010 Sep 15;5(9):e12746. doi: 10.1371/journal.pone.0012746

Figure 1. Delayed wound healing in tPA-deficient mice after systemic treatment with a monoclonal anti-uPA antibody, mU1.

Figure 1

A, The percentage of mU1-treated and anti-TNP-treated tPA-deficient (tPA−/−) mice as well as uPA;tPA double-deficient (uPA−/−;tPA−/−) mice with wounds that have healed completely are depicted in a Kaplan-Meier plot, n = 9–14. B, The mean healing time with increasing doses of mU1 administration to tPA-deficient mice compared to control mAb-treated (anti-TNP) as well as to uPA;tPA double-deficient (uPA−/−;tPA−/−) mice. Mann-Whitney unpaired t-test was applied to statistically compare healing of mU1-treated and control mAb (anti-TNP)-treated mice. *** indicates p-values, i.e. * p<0.05, ** p<0.005, and ***p<0.0001.