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. 2010 Sep 15;5(9):e12716. doi: 10.1371/journal.pone.0012716

Figure 3. A congenic strain confirms the influence of Eae23 on EAE in females and males.

Figure 3

Daily EAE scores in parental DA and congenic DA.PVG-Eae23 demonstrate that congenic strains with PVG alleles in Eae23 are protected from EAE. A) Females; DA N = 12 and DA.PVG-Eae23 N = 13. B) Males; DA N = 22 and DA.PVG-Eae23 N = 21. C) Females; DA N = 16, DA.PVG-Eae23 N = 13 and heterozygous DA.PVG-Eae23 N = 13. Females are represented by circles and males are represented by squares. Mann-Whitney U-test was used to compare the daily EAE scores; p values ≤0.05 were considered significant and is indicated by *. Abbreviations: D.P-Eae23 =  DA.PVG-Eae23, Eae23-H  =  heterozygous DA.PVG-Eae23, p.i.  =  post immunization. Vertical bars represent standard error of the mean (SEM).