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. 2010 Sep 15;5(9):e12716. doi: 10.1371/journal.pone.0012716

Figure 8. Differential ZEB1 isoform expression in DA.PVG-Eae23 and DA.

Figure 8

Differential gene expression of ZEB1 is driven by a splice-variant specific shift in balance. In lymph nodes collected day 7 p.i. from parental DA and DA.PVG-Eae23 (A – D), mRNA expression of Zfhep2 is up-regulated in the congenic strain compared to parental DA. In spleen collected day 35 p.i. (E – H), Zfhep1 is up-regulated while Zfhep2, ZEB1 and IL2 are down-regulated in DA.PVG-Eae23 compared to parental DA. Median values are indicated by horizontal bars. Mann-Whitney U-test was used to compare the mRNA expression; p values ≤0.05 were considered significant, *  = p≤0.05 and **  = p≤0.01. Abbreviations: D.P-Eae23 =  DA.PVG-Eae23, RQ  =  relative quantity. A and E) ZEB1  =  Zinc finger E-box-binding homeobox 1, B and F) IL2  =  Interleukin 2, C and G) Zfhep1  =  splice variant 1 of ZEB1 (NP_037296.1) D and H) Zfhep2  =  splice variant 2 of ZEB1 (ZEB1).