Table 4. CNS Histopathology demonstrates protection from EAE in DA.PVG-Eae23.

	DA	DA.PVG-Eae23
	Mean (SD)	Mean (SD)
Weight at immunization (grams)	162.9 (9.5)	153.5 (16.7)
Adjusted dose (µg MOG/g rat)	0.092 (0.005)	0.099 (0.011)
Incidence (%)	89 (33)	69 (48)
Day of Onset (day p.i.)	15.6 (9.4)	22.5 (12.9)
Max EAE Score	2.7 (1.2)	1.5 (1.3)*
Duration (days)	20 (8.5)	10.1 (9.5)*
Cumulative EAE score	46.8 (28.4)	15 (17)*
Spinal Cord Demyelination	1.8 (1.6)	0.09 (0.3)*
Spinal Cord Inflammation Index	0.58 (0.46)	0.14 (0.29)*
Brain Demyelination	2.6 (1.8)	0.35 (1.1)*
Demyelination in Optic Nerves	7/9	2/13*
Pons Involvement	1/9	0/13

Mann-Whitney U-test was used to compare histopathology phenotypes between parental DA and DA.PVG-Eae23; p values ≤0.05 were considered significant, indicated by *.

Abbreviations: SD  =  standard deviation, p.i.  =  post immunization.