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. 2010 Sep 15;5(9):e12766. doi: 10.1371/journal.pone.0012766

Figure 7. ADAM8−/− thymocytes migrate less efficiently through matrix in response to CCL21.

Figure 7

Migration efficiency [% of input] of wt and ADAM8−/− (A) DN, (B) DP, (C) CD4 and (D) CD8 thymocytes in transmigration assays in response to CCL21 in the presence or absence of Fibronectin. (E) Flow cytometry plots showing CCR7 expression on wt and ADAM8−/− CD4 and CD8 thymocytes detected with CCL19-Fc. (F) Numbers of donor-derived cells 10 days after intrathymic injection of wt bone marrow cells into wt or ADAM8−/− mice. Data in (A–D) are representative of three independent experiments performed in triplicates. Data in (E) are representative of two independent experiments with n≥3 age- and gender-matched mice per group in each experiment. Data in (F) are representative of two independent experiments with n≥4 age- and gender-matched mice per group in each experiment. Data are presented as mean values and error bars as SEM. **, p<0.01.