Table 7.
NOS2 haplotype associations with anemia outcomes in Muheza, Tanzania
| Na (% total) | Anemia |
|||
|---|---|---|---|---|
| HGB <5 | HGB < 6 | HGB < 8 | ||
| OR (95% CI)b | OR (95% CI)b | OR (95% CI)b | ||
| C-1173T haplotype (at least 1 vs. none) | ||||
| Univariate model | 49 (6.7) | 1.97(0.47, 8.29) | 1.14 (0.37, 3.49) | 1.49(0.85, 2.61) |
| p =0.36 | p = 0.82 | p = 0.16 | ||
| Multivariate model | 49 (6.7) | 2.68 (0.67, 10.70) | 1.32 (0.44, 4.01) | 1.74 (1.00, 3.02) |
| p =0.16 | p = 0.62 | p = 0.05 | ||
| Number of cases | 17 | 42 | 174 | |
a
Number of infants with at least one of the specified haplotype(s)
b
Odds ratio and 95% confidence interval acquired from GEE univariate models and acquired from GEE multivariate models adjusted for: gravidity (primigravid, secundigravid, or multigravid), placental malaria (positive or negative), residence location (four geographical areas), bed net usage (treated, untreated, none, or unknown), birth weight (low or normal) season at birth and at clinic visit (high or low), age at clinic visit. Models were also adjusted for HbS (AA or AS) and thalassemia as well as their interaction