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Second in vivo trial against P. berghei, with dosage adjusted to be equimolar to 30 mg/kg CQ. Historical data for CQ is included for comparison.
| Drug | Dosage (mg/kg) |
Route | % Activity | Mouse survival (days) |
|---|---|---|---|---|
| CQ | 4 × 30 | Oral | 99.9 | 23 (3/10 mice cured) |
| 21 | 4 × 44 | Oral | >99.9 | >30 (3/3 mice cured) |
| 22 | 4 × 46 | Oral | >99.9 | 30 (9/10 mice cured) |
