Table 1.

Gene expression analysis in liver.

	Chow1		High fat
gene	rel exp2	Sig3	rel exp	Sig3	diet WT4	diet Tgif−/−
Tgif2	2.89	*	1.68		0.87	0.51
Abca1	0.72		0.72		0.29	0.29
Abcb11	0.97		0.55		3.19	1.80
Abcb4	1.77	*	0.95		7.70	4.14
Abcg1	0.91		1.74		0.97	2.03
Abcg5	1.58		1.06		22.79	15.29
Abcg8	2.23	*	0.96		14.10	6.05
Acaca	1.56	**	1.69		0.06	0.06
Acacb	1.13		2.53	***	7.92	17.80
Angptl3	0.83		0.85		4.45	4.56
Cd36	1.05		0.88		2.38	1.98
Cyp7a1	0.77		0.37	**	39.41	19.00
Dgat1	0.77	**	0.67		0.71	0.61
Dgat2	1.02		1.10		0.78	0.84
Fasn	1.07		1.49		0.81	1.13
Lpl	1.03		1.06		1.16	1.19
Scarb1	0.70	**	0.73		0.33	0.34
Scd1	1.26		1.28		3.79	3.86
Hnf4a	1.28	**	0.62	***	4.63	2.25
Chrebp1	0.90		0.69		0.53	0.41
Couptf2	0.98		0.80		2.21	1.80
Foxo1	1.08		0.78	*	1.78	1.29
Lrh1	1.38		0.94		1.26	0.85
LXRa	0.94		0.78		3.64	3.03
Pgc1a	1.96	*	0.94		1.76	0.84
Shp	0.74		0.75		0.28	0.28
Srebf15	0.66		1.29		2.53	4.92
Srebp1c	0.80		1.00		4.24	5.31

Notes

¹Mice were maintained on a normal chow diet or fed a high fat, high cholesterol diet for 15 weeks.

²Expression is shown as Tgif null relative to wild type, for each diet.

³Significance was analyzed by student’s T test.

^*p < 0.1;

^**p < 0.05;

^***p < 0.01.

⁴Expression is compared between diets for each genotype.

⁵Expression of Srebf1 (including both Srebf1 isoforms), and the Srebp1c isoform alone were analyzed.