Figure 12.

The β-2 AR selective antagonist ICI-118551 but not the β-1 AR selective antagonist betaxolol blocks stress-induced reinstatement. Data in (a) represent the time spent in the cocaine (Coc) compartment (sec±SE) during the final extinction session prior to reinstatement testing (Ext) and during reinstatement testing after forced swim (FS) following pretreatment with vehicle (V) or betaxolol (Bet; 10 mg/kg, i.p.; n=11). A significant main effect of FS (^*p<0.05) but no FS × Bet interaction was found. The effect of ICI-118551 (ICI; 1 mg/kg, i.p.; n=11) on FS-induced reinstatement is shown in (b). A significant interaction between FS and ICI was found (p<0.05). Post-hoc testing showed that FS increased time spent in the cocaine compartment after treatment with V (^#p<0.05) but not ICI.