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. 2010 Jul 21;35(11):2292–2304. doi: 10.1038/npp.2010.107

Figure 1.

Figure 1

Dopamine effects on the amplitude of synaptically evoked IPSCs. (a) In saline-treated animals, bath application of 20 μM DA produced a temporally biphasic effect on the amplitude of eIPSCs, resulting in an initial decrease followed by a prolonged increase in the amplitude of the eIPSC. Top: representative traces of eIPSCs at three different time points. Traces are averaged sweeps of 10 responses during baseline, or ‘early' (5–10 min after DA bath application) and ‘late' (25–30 min after DA bath application) time periods used to measure drug effects. Bottom: group data showing the time course of eIPSC amplitude changes in saline-treated animals (n=8). Changes in amplitude are relative to the averaged response of the baseline period. The large vertical bar indicates the duration of DA application. Small horizontal bars indicate the periods from which averaged measures were used for statistical comparisons of ‘early' (black bar) and ‘late' (gray bar) drug effects. The numbers above the bars indicate the mean (±SEM) percentage change in amplitude during these periods. (b) Bottom: in cocaine-treated animals (n=7), the initial reduction in eIPSC amplitude was absent and instead the eIPSC amplitude showed a rapid and persistent increase. Top: Representative traces of eIPSCs for the same time periods as indicated in (a).