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. 2010 Jul 21;35(11):2292–2304. doi: 10.1038/npp.2010.107

Figure 4.

Figure 4

Pharmacology of dopamine modulation of spontaneous IPSCs in saline- and cocaine-treated animals. (a, b) Time course of changes in sIPSC frequency following D2 receptor stimulation with quinpirole (5 μM) in saline- (a) and cocaine-treated (b) animals. In saline animals, (n=6) there was a slowly developing reduction in the number of sIPSCs that became significant by the time of the late measurement period (see d). In cocaine-treated animals there was no discernible effect of D2 receptor stimulation. (c) In contrast, D1 receptor stimulation with SKF-81297 produced a rapid and persistent increase in the frequency of sIPSCs in cocaine-treated animals (n=6). Similar increases were seen with bath application of 100 nM DA (see d). (d) Summary graph showing the average changes in sIPSC frequency during the early (5–10 min following drug application) and late (25–30 min following drug application) measurement periods for the data shown in (a–c), as well as results obtained with bath application of 100 nM DA (n=8; *p<0.05, **p<0.01, paired t-tests).