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. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Bioconjug Chem. 2010 Sep 15;21(9):1691–1702. doi: 10.1021/bc100292x

Figure 5.

Figure 5

Effect of K7A/D38R/R39D/G88R RNase A and (G88C RNase A)3–8 on the tumor volume and body weight (insets) of Balb c(−/−) mice in xenograft models bearing human DU 145 prostate tumors. Data points are the mean (± SE) for n mice; % TGI values in parentheses were calculated with eq 5. Vehicle control (○; n = 7). (A) K7A/D38R/R39D/G88R RNase A (■, 5 mg/kg; ▲, 15 mg/kg; ◆, 45 mg/kg; i.p., qd×5; n = 7). (B) K7A/D38R/R39D/G88R RNase A (●, 15 mg/kg; i.p., qd×5; n = 7), ONC (□, 5 mg/kg; i.p., 1×wk; n = 7). (C) K7A/D38R/R39D/G88R RNase A (●, 75 mg/kg; i.p., 1×wk; n = 7) and docetaxel (□, 15 mg/kg; i.p., 1×wk, n = 7, though 4 mice died during the course of the experiment such that n = 6 on day 28, n = 5 on day 35, n = 4 on day 49, and n = 3 on day 63). (D) (G88C RNase A)3–8 (▲, 25 mg/kg; i.p., 1×wk, n = 7).